A novel heme degradation pathway in a blood-sucking insect
نویسندگان
چکیده
Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968-0519, USA Departamento de Parasitologia, Universidade de Sao Paulo, Sao Paulo, SP 05508-900, Brazil Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, 21045-900, Brazil Department of Biochemistry and Molecular Biophysics; Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
منابع مشابه
A heme-degradation pathway in a blood-sucking insect.
Hematophagous insects are vectors of diseases that affect hundreds of millions of people worldwide. A common physiological event in the life of these insects is the hydrolysis of host hemoglobin in the digestive tract, leading to a massive release of heme, a known prooxidant molecule. Diverse organisms, from bacteria to plants, express the enzyme heme oxygenase, which catalyzes the oxidative de...
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Self-mutilation is defined as intentional damaging of the body without intention to die. Patients with borderline personality disorder frequently mutilate themselves by means of cutting, burning and abrading their skin. In this case report, a patient with borderline personality disorder is described who has cut his skin and suck his blood Several times. He had also the history of killing pigeon...
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A blood-sucking habit appeared independently several times in the course of arthropod evolution. However, from more than a million species of insects and arachnids presently living on earth, only about 14,000 species developed the capacity to feed on vertebrate blood. This figure suggests the existence of severe physiological constraints for the evolution of hematophagy, implying the selective ...
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Heme and iron are essential molecules for many physiological processes and yet have the ability to cause oxidative damage such as lipid peroxidation, protein degradation, and ultimately cell death if not controlled. Blood-sucking arthropods have evolved diverse methods to protect themselves against iron/heme-related damage, as the act of bloodfeeding itself is high risk, high reward process. Pr...
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Background and Objective: Some evidence about the relationship between heme oxygenase and many cancers is available. Heme oxygenase has anti-apoptotic effects and contributes to tumor growth. The aim of this study was to evaluate the effect of heme oxygenase on melanoma tumor cells mitosis and tumor size in C57BL/6 mice. Materials and Methods: B16F10 melanoma cells were injected subcutaneously ...
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